Tag Archives: mesothelin

TCR2 Tx Completes Gavo-Cel’s Ph1 Trial; Dosing Started in Gavo-cel’s Pivotal Ph2 Study; Gilead’s KITE-222 Receives Orphan Drug Designation

On Wednesday, September 28, 2022, TCR2 Tx held an investor event highlighting positive topline results from gavo-cel’s (TC-210; autologous mesothelin TRuC-T) Ph1 portion of the Ph1/2 trial (press release / presentation). On Tuesday, September 27, Gilead’s (Kite) KITE-222 (autologous CLL-1 CAR-T) was granted Orphan Drug Designation (ODD) by the FDA (FDA Designation). Below, Celltelligence provides insights on gavo-cel’s positive clinical results and future pivotal development as well as discusses KITE-222’s ODD in AML.

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The Celltelligence team has combined experience in oncology, including cell therapy, CAR-T, immunology, microbiology, biochemistry, and other various fields in life sciences. Our team members include PhDs, industry veterans, and analysts tuned to The Street – all of whom help to create a more actionable service of delivering cell therapy intelligence.

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Thoughts on Bayer’s and Atara’s Collaboration to Develop Solid Tumor CAR-T Therapies

On Sunday, December 6, Bayer and Atara Biotherapeutics announced (Bayer press release / Atara press release) a collaboration and worldwide license agreement. The collaboration covers research, development, and manufacturing milestones for mesothelin-targeting CAR-T therapies in high mesothelin-expressing solid tumors. Of note, the agreement includes the development of ATA2271 (an autologous mesothelin-targeting CAR-T) and its allogeneic version ATA3271 to treat malignant pleural mesothelioma and non-small-cell lung cancer. Below, Celltelligence provides thoughts on Bayer’s growing cell therapy portfolio, a possible strategy for advancing cell therapies, and if they will license Atara’s allogeneic CD19 CAR-T.

About The Author

The Celltelligence Team

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Content Leads & Contributors

The Celltelligence team has combined experience in oncology, including cell therapy, CAR-T, immunology, microbiology, biochemistry, and other various fields in life sciences. Our team members include PhDs, industry veterans, and analysts tuned to The Street – all of whom help to create a more actionable service of delivering cell therapy intelligence.

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